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The strongest human evidence is for the intranasal route : small Russian clinical trials in generalized anxiety and neurasthenia reported anxiolytic effects comparable to medazepam , but without the sedation or dependence typical of benzodiazepines [1] [2]

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The honest answer is that the human safety data is limited compared to decades-old pharmaceuticals, but the preclinical safety record across multiple species is unusually clean for a peptide with this level of biological activity

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