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A level of 80g/10 units a day Gastrointestinal disorders: coeliac or any disorder affecting the small bowel Pregnancy: preferential delivery of folate to foetus rather than mothers tissues, deficiency in utero increases the risk of neural tube defects Haematological disorders: increased red cell destruction (sickle cell anaemia, haemolytic anaemias) and those with abnormal haematopoiesis Exfoliative skin disorders (e.g

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Analyst 126 (6), 816820

RM ANOVAs indicated significant interactions of treatment x time during wakefulness (F 11,88 = 2.51, p = 0.009, 2 p = 0.24, Figure 3A) and NREMS (F 11,88 = 2.7, p = 0.005, 2 p = 0.25, Figure 3B)