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Description
Shikonin induces ferroptosis in multiple myeloma via GOT1-mediated ferritinophagy
The phases are best thought of as escalation stages: Induction (Step 1, ~weeks 14): 2 mg weekly
Genetic and environmental influences interact with age and sex in shaping the human methylome
By explicitly bringing these advanced therapeutic products under the CLAA framework, the regulation strengthens regulatory clarity, promotes standardized licensing, and supports the safe development and commercialization of innovative biological products
