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In lipopolysaccharide (LPS)-induced oxidative stress, ALA (60 mg/kg, IV) treatment alleviated neurophysiological symptoms, normalized TBARS and H 2 O 2 levels, and improved the GSH/GSSG ratio, indicating enhanced antioxidant defense [77]
Based on these results, the company plans to launch a new phase 3 Programme called RENEW later this year

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Significant increases were observed in the amounts of certain flavonoids and non-flavonoid compounds, particularly rutin and epicatechin (158)
