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The method of any one of embodiments 1-64, wherein the therapeutic agent is released from the formulation over a period of at least 14 days

Interestingly, it is worth noticing that BBB as a carrier is extremely pivotal since glucose (also called fuel for the brain) transportation is vital for the appropriate functioning of the human brain and around 20% of the total body energy is used by the brain to work effectively [3, 6]

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Understanding the mechanism helps explain why its effects are so broad
