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And when it comes to health fitness, common confounding variables are all over the place, because we're human beings, we live messy lives, our stress levels change, our sleep quality changes, we have seasonal variations in our activity

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(ii) GxG (Gene x Gene) interaction, wherein the loss of two genes leads to a fitness phenotype that is not the simple additive sum of two single KOs, and (iii) GxGxE (Gene x Gene x Environment) interaction, wherein the impact of the pairwise genetic interaction is dependent on the metabolic state