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PLoS ONE 2012, 7, e37779
doi: 10.1146/annurev.nutr.26.061505.111258 364 HotamisligilGS
Initial findings from larger clinical trials using anti-IGF neutralizing antibodies were discouraging, as a Phase Ib/II study of xentuzumab, exemestane, and everolimus (mTOR inhibitor) combination therapy for advanced HR + breast cancer (NCT02123823) was discontinued early due to no change in PFS in the overall participant population [169]
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