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Using HD mouse and cell models, we demonstrated that TFEB and TFE3 are sequestered in muHTT aggregates, and muHTT proteins associates with LMP triggering the translocation of LGALS3 to the lumen of lysosomes, with a close relation between polyQ size and severity of these events
Anaerobic bacterial metabolism of DCM has not yet been taken into consideration as a factor in the global DCM cycle
Dosage, frequency, and number of sessions are determined by a doctor based on individual assessment
