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These substitutions protect against dipeptidyl peptidase-IV (DPP-IV) cleavage, the enzyme that destroys natural GHRH within minutes (Alba et al., J Med Chem 2006)
However, since there can be so many causes for these symptoms, health care providers may overlook the possibility of a B12 deficiency and fail to screen for it
how could this peptide have any systemic activity?
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