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First, as this study was an open-label and nonrandomized study, we could not clearly determine whether the metabolism change over time in the children participating in the study was due to folic acid treatment specifically, or to placebo effects

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37 Furthermore, even if CRF application protects against gastric ulcers, 38 exogenous administration of CRF can reproduce cardinal features of diarrhea predominant irritable bowel syndrome including anxiogenic behavior, enhanced visceral pain to colorectal distention, increased colonic mucus secretion, propulsive motility, development of watery stool/diarrhea, and increased colonic mucosal permeability facilitating bacterial translocation into colonic tissue