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Description
These mutations result in mitochondrial dysfunction, including mtDNA mutations, deletions, or depletion

Grosskreutz, Calcineurin cleavage is triggered by elevated intraocular pressure, and calcineurin inhibition blocks retinal ganglion cell death in experimental glaucoma
Collectively, this evidence solidifies the core position of SGLT2 inhibitors in DN management, providing vital therapeutic options for clinical practice

doi: 10.1002/eji.201142290 281 HanGGengSLiYChenGWangRLiXet al
