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The issue is not glutathione itself

Similar observations were made in aortic tissue slices, where FOXO4-DRI treatment led to increased expression of p-P53, mainly localized in the cytoplasm (Figures 5F,G)

Statements Data availability statement The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding authors

But long-term GH replacement therapy (which produces similar GH/IGF-1 levels) has been studied for decades and is considered safe when properly monitored
