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Endothelial dysfunction arises when endothelial cells (EC) are injured, or if there is an imbalance between vasoconstriction and vasodilation (Russell et al., 1989

In vivo experiments further demonstrated that Irisin-loaded bone marrow mesenchymal stem cell-derived exosomes significantly inhibited activation of the YAP/EGR1/ACSL4 signaling pathway in the brains of middle cerebral artery occlusion (MCAO) mice, suppressed ferroptosis and lipid peroxidation, thereby mitigating ischemic brain injury (Fang et al., 2025)

83,185,188,189 Genetically engineered mouse models of pancreatic ductal adenocarcinoma (PDAC) 83,188 and CRC 190-192 showed that the TGF- pathway interferes with the transition of pre-malignant cells to the carcinoma stage during malignant progression

doi: 10.1038/sj.embor.7400445