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Endothelium-dependent vascular relaxation was assessed by measuring the amount of active contractile force that remained during exposure to increasing concentrations of ACh (10 10 M-10 6 M)

TJs do not influence the permeability of lipophilic molecules, but hydrophilic molecules must traverse this barrier [67]

Furthermore, clinical evidence implicates ApoE4s interaction with A is related to increased Tau deposition in AD vulnerable regions in the brain (Therriault et al., 2021), which mirrors the importance of A in the acceleration of AD Tau dynamics (Lee et al., 2022)

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