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The molecule was first identified and studied by the Sikiric research group in Croatia starting in the early 1990s, and the bulk of the preclinical evidence base comes from more than three decades of rat and rodent studies showing consistent tissue-repair, anti-inflammatory, and gastroprotective effects

doi: 10.1182/blood-2013-11-540526 78 O BrienLKerriganSWKawGHoganMPenadsJLittDet al

Finally, further studies should clarify the molecular pathways involved and extend the one-time application (much like the engraftment of neural stem cells [16] or bone marrow stromal cells [17] into the lesion site) to the continuous application for the recovery of pre-existing spinal cord injury