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Early exploratory studies have examined whether AOD9604's signaling properties could support connective tissue repair under mechanical stress, and a rabbit osteoarthritis model study investigated intra-articular injection of AOD9604, in some cases alongside hyaluronic acid, as a research approach to joint tissue changes

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The most powerful system is the first-line antioxidant defense system, which comprises antioxidant enzymes, such as superoxide dismutases (SODs), catalase (CAT), and glutathione peroxidases (GPxs)