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Notably, preclinical studies in animal models first demonstrated this synergy co-administration of an amylin analog with a GLP-1 analog produced far greater weight loss than either agent alone paving the way for trials of the combination in humans

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In addition, a phase II trial demonstrated the efficacy of sorafenib in combination with docetaxel and cisplatin for the treatment of advanced GC, with an mOS of 13.6 months (114) and the most common grade 3/4 adverse reactions being neutropenia

Macrophages in mouse type 2 diabetic nephropathy: correlation with diabetic state and progressive renal injury