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In animal-based studies, some withdrawal studies have included tremors, cravings, and increased stress that arise as a consequence of increased CRF levels (99)

[DOI] [PMC free article] [PubMed] [Google Scholar] 56.Guan Z.H., Zhou L.M., Zhang Y., Chen H.P., Shao F.F

However, in the long term, if more and more agents from existing clinically safe drugs are used and proven in clinical applications for health span extension, it is likely that more anti-aging agents from synthetic compounds will emerge in the future

Neurologic manifestations are caused by progressive demyelination and can include peripheral neuropathy, areflexia, and the loss of proprioception and vibratory sense