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Description
BPH, Benign prostatic hyperplasia
and (3) cholesterol homeostasis disruption caused by bile acid metabolism dysregulation
Together these up- and downregulated genes in DTG-exposed organoids are consistent with a cumulative effect on human forebrain organoid development, including dysregulation of amino acid signaling in neural progenitors, leading to the induction of cellular stress responses and a disruption of transcriptional programs that support cortical neurogenesis
Risk of bias assessment The results of evaluating the quality of the included studies are presented in online Supplementary Fig
