glutathione and nadph does reduce Cellular mechanisms controlling oxidative stress. NADPH is an essential It favors its accumulation in the regions of high electron flux in cells where reactive species are generated. Mitochondrial Glutathione: Regulation and Functions
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It also noted that as B12 deficiency increased, so too did insulin resistance

Spotting in between periods is also common for women with endometriosis
A cross-sectional study of 700 community-living, physically disabled women over the age of 65 found that vitamin B 12 -deficient women were twice as likely to be severely depressed as non-deficient women (97)

And that brings us back to the central question
