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Human data on piperlongumine are missing, apart from a single clinical study in Japanese women which showed that Piper longum extract increased peripheral blood flow and skin temperature after cold stress [99]

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Cholesterol ( m/z = 386.3), 7-dehydrocholesterol ( m/z = 384.3) and 4-methyl-5-cholest-8(14)-en-3-ol/lophenol ( m/z = 400.3) were identified by comparison of elution profiles and fragmentation patterns with reference to the NIST database and cholesterol as well as 7-dehydrocholesterol standards