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have found that during MMP, p62 may induce autophagy by binding to the ubiquitinated VDAC1 protein localized on the OMM [278]

This convergence provides a mechanistic basis for the observed lifespan extension, frailty attenuation, and normalization of age-associated molecular drift

For instance, Vardi et al

therefore studies on men and women over the age of 50 yr demonstrated no differences for homocysteine levels between healthy women and men (269)
