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Regulatory networks involving oxidative stress and related pathways are widely represented in hypopigmentation diseases, particularly vitiligo

Berbamine-mediated excess ROS negatively regulates the NF-B pathway by means of activation of NF-B inhibitor (IB) and oxidation of cysteine in the binding region of NF-B to DNA, thereby inhibiting the development of bladder cancer (Han et al., 2021)

By resisting immediate degradation, the sustained-release formula allows the intact tripeptide to gradually enter the intestinal tract, where it is slowly absorbed over an extended period

However, it remains elusive whether GSSSG exerts similar inhibitory effects on other retinal cell types including glial cells, which are major sources of proinflammatory cytokines in pathological conditions