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Adverse events: Injection-site reactions remained the most common side effect Mild headaches reported by some subjects Occasional nausea (usually mild and transient) No serious adverse events attributed to the peptide Dropout rates similar to placebo groups Metabolic safety: No adverse effects on blood glucose or insulin sensitivity No changes in blood pressure or heart rate No effects on thyroid function Improvements in lipid profiles (a beneficial effect) Common Side Effects Injection-site reactions: The most commonly reported AOD9604 side effects are injection-site reactions, including: Mild redness at the injection site Slight swelling or firmness Minor discomfort or tenderness Occasional bruising These reactions are usually mild and resolve within 2448 hours

2001, AOD-9604 lost most of this fat-metabolism effect in mice that were genetically missing the beta-3 adrenergic receptor, suggesting that pathway carries part of the signal

A 2023 randomized controlled trial demonstrated that semaglutide significantly reduced testosterone levels and improved menstrual regularity in women with PCOS, with hormonal effects extending beyond what weight loss alone could explain

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