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Parenteral B12 use: Deficiency of B12 causes megaloblastic anemia and neurological symptoms (fatigue, tingling, memory problems)
The molecular target that AOD-9604 actually binds is still unidentified, which the FDA explicitly noted in its December 2024 evaluation
Importantly, animals were singly housed to eliminate the exchange and cross-contamination of intestinal microbiomes, a factor that potentially biases studies with group-housed animals by minimizing microbiome variations for co-housed animals within a cohort
