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When tissues are deprived of oxygen, they are forced into anaerobic metabolism, which generates excessive protons and creates a highly acidic local environment

On the other hand, when there are altered basal blood glucose levels or glucose intolerance, triglycerides (TG) levels and the 8-OHdG adduct are increased [222]

de Chateau, M

It is known that fructose can be further metabolized to produce 3deoxyglucose and fructose3phosphate, both of which are very potent nonenzymatic glycation agents.76 On the other hand, as fructose metabolism by fructokinase, with the consumption of ATP, can bypass the regulation of the glycolytic pathway,77, 78 acetylCoA could be overproduced78 and ATP could be depleted.79 AcetylCoA overproduction could cause nonalcoholic fatty liver disease (NAFLD), as acetylCoA is the precursor of fatty acid,77, 80, 81, 82 while ATP depletion could cause cell death