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It has been reported that the (D or L)-HB scavenge ROS, while the ACA scavenges ROS species when their concentration exceeds physiological range (IC50 2067 mM) ( in vivo model of hypoglycemia, where (D or L)-HB prevented hippocampal lipid peroxidation, while ACA did not exhibit this effect ( In vivo studies in mice that fed on KD suggested neuroanatomical variation with antioxidant capacity, and the most significant changes were observed in the hippocampus, as well as increased glutathione peroxidase level and total antioxidant capacities ( KD, ketone esters or HB administration exerts neuroprotective effects as reported in models of a variety of neurological diseases ( In summary, most of the previous reports associated KBs with the attenuation of oxidative stress, as they inhibited ROS production, prevented lipid peroxidation as well as protein oxidation, and increased the levels of antioxidant proteins

doi: 10.1016/j.diabres.2022.109813 47 OrkabyARDushkesRWardRDjousseLBuringJELeeIMet al

Proc Natl Acad Sci U S A 117(40):25026-35 2020 PMC7547280 Young BA

Iodomethylcholine inhibits trimethylamine-N-oxide production and averts maternal chronic kidney disease-programmed offspring hypertension