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Although prior work indicates that ferroptosis acts as a central hub linking reactive oxygen species to autophagy and apoptosis, this study does not establish its priority within the cascade of oxidative stress, neuroinflammation, and multimodal cell death, particularly regarding microglial ferroptosis and its contribution to secondary neuronal injury

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ATP serves as a substrate for SAM synthesis by MAT, while ADP and AMP can allosterically regulate enzyme activity