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MATERIALS AND METHODS We performed a systematic review of the literature, using Ovid MEDLINE databases and reference lists of retrieved articles

Cui H, Zhang N, An J, Zeng X, Zhao Y, Sun X, et al

Suggested mechanisms include an imbalance in energy metabolism due to tumor growth, infection, fever, or surgery, malnutrition caused by anorexia, nausea, or vomiting, and an increase in the abnormal production of substances that impair metabolic homeostasis, such as cytokines and proteolysis-inducing factors (2)

Resveratrol triggered apoptosis via the involvement of mitochondrial pathway in fibroblast-like synoviocytes derived from patients with rheumatoid arthritis [139] and was proved as an effective adjuvants in the management of rheumatoid arthritis patients [140]