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For example, compounds such as Biochanin-A (BCA) ( Inonotus sanghuang extract (ISE) from ethyl acetate fraction (Su et al., 2021), salvianolic acid B (Liu et al., 2016), total ginsenosides (TG) (Yang et al., 2019), Dendrobium officinale (Yu et al., 2019), and low molecular weight fucoidan (LMWF) (Wu et al., 2021) were shown to effectively inhibit this signaling in bleomycin-induced mouse models of pulmonary fibrosis

This is particularly significant for patients with premature ovarian failure, as oxidative stress is a critical factor contributing to ovarian dysfunction

Hence, although the WD40 is favored by several clients in binding assays, it is often not suitable for co-crystallization with client peptides

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