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Second, the needles themselves create controlled micro-trauma, which triggers a wound-healing response and further stimulates collagen production (El-Domyati et al., 2012)

Altered DJ-1 function, its overoxidation to sulfonate form (-) at the cysteine-106 and ubiquitination, were reported in the pathophysiological response to oxidative damage and emphysema patients (17)

In this context, the modulation of glutamine on relevant signaling pathways as nuclear factor kappa B (NF-kB), mitogen-activated protein kinases (MAPKs), and heat shock protein and the influence of this amino acid on cell migration and adhesion molecules are highlighted