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This data suggests that while lower doses (5-15g) are excellent for maintenance and mild IBS, repairing severe, pathological "leaky gut" may require transient, high-dose interventions under medical supervision to rapidly force the reassembly of tight junction proteins

For example, IL-2 treatment has been shown to increase Treg numbers and reduce inflammation in COPD models (123)
B., van Rooijen, N
This polymorphism is in intron 13 of the MAO-B gene and is thought to disrupt monoamine metabolism, leading to increased ROS production and oxidative stress within the central nervous system (Leko et al., 2021)
