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The primary concern is additive nausea, as both compounds can independently cause gastrointestinal discomfort

For example, NO may hinder the nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase complex, resulting in a decreased production of superoxide anions and a reduction in the synthesis of peroxynitrite, which can be harmful to cells [22]

No significant differences were found in the prevention of cisplatin-induced hearing loss from 0.5 to 8 kHz using either systemic or transtympanic N-acetylcysteine administration compared to placebo, although qualitative analyses suggested a tendency to otoprotection in ultra-high frequencies (10 and 12 kHz) (116)

Lifestyle Changes In addition to diet, certain lifestyle changes can significantly impact glutathione levels: Regular exercise, which boosts the body's antioxidant defenses and stimulates glutathione production