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The details of these trials are summarized in Table 1

Regarding the type of AEs, 18 patients (13.1%) reported insomnia, 15 patients (10.9%) reported widespread shivering, 10 patients (7.3%) reported headache, and 5 patients (3.6%) reported nausea (Table 3)

-Butyrobetaine is then converted to L-carnitine in a reaction catalyzed by -butyrobetaine dioxygenase, an enzyme that is only expressed in kidney, liver, and brain [40, 41]

The questions are very relevant in this group of patients, because the primary prophylactic treatment strategy was e.g
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