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5 Conclusion Therefore, the mitochondrial dysfunction observed in aging is accompanied by the intracellular GSH/GSSG imbalance, a decrease of the H 2 S content in organelles and the expression levels of UCP3 , as well as the uncoupling of mtNOS with an increase in ROS production, disruption of Ca 2+ homeostasis, etc., which leads to the induction of mPTP with high conductance and causing cardiac dysfunction

326 Upon RT activation, Hsp60 immediately dissociates from the Hsp60/RT complex without being encapsidated into viral nucleocapsid

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It allows for rapid absorption by delivering the medication directly into the bloodstream through the nasal mucosa (lining of the nasal passages), avoiding the digestive system