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Histamine takes part in the pathophysiology of IBS and increases intestinal permeability and visceral hypersensitivity (82)
High Tolerability: In human trials involving over 900 subjects, no anti-peptide antibodies or significant adverse events were reported

It is generally avoided in pregnancy, in people with certain gastrointestinal conditions, and where a clinician identifies a contraindication during screening

In addition, B12 works synergistically with other B vitamins, such as B6 and folate, to support overall cardiovascular health by promoting healthy blood vessel function and reducing inflammation
