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After IM injection, the onset of analgesia occurs in about 30 minutes, with a peak effect around 1 to 2 hours, and a duration of action of 4 to 6 hours

[DOI] [PubMed] [Google Scholar] 110.dAnjou MA, Penninck D, Cornejo L

Additionally, A1AT may have a diminished ability to bind PR3 and counteract its proteolytic effect on vessels
