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In a trial involving 77 individuals with a body mass index of 25 kg/m 2 or higher (age = 53.2 0.7 years), eight weeks of supplementation with lions mane extract led to significant improvements in depression (29.4%), anxiety (33.2%), and sleep disorders (39.1%) compared to baseline

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But some men experience insufficient results, intolerable side effects, or plateau effects that limit their effectiveness

The PYC-treated groups received PYC eye drops as an individual drop (0.05 mL) to the mid cornea of the injured eye three times daily for 6 d, and the NC-groups were remedied with vehicle (saline) eye drops in the same means as described [19]