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The pathophysiology of PASC is described right from the initiation of the novel SARS-CoV-2 infection by primordial hijacking of host cellular metabolic machinery, subsequent progression of virus-induced human metabolic reprogramming/dysregulation (HMRD) in a susceptible host, subjecting the patient through a crucial tri-phasic symptomatic clinical onset of COVID-19 (lasting from 34 weeks), and ultimate transition of a survivor into PASC or long-COVID, a virus-free state, lingering with earlier and/or new onset disease manifestations resulting from pre-acquired HMRD (lasting for weeks to months)

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Professor Sikirics research contributions include: Initial isolation and characterization of BPC-157 from human gastric secretions Extensive investigations of gastroprotective and multi-organ tissue healing mechanisms Pioneering studies on musculoskeletal tissue repair including tendon, ligament, and muscle healing Research on cardiovascular protective effects and vascular injury healing Investigations of BPC-157 interactions with nitric oxide pathways and growth factor systems Over 100 published papers examining BPC-157s pleiotropic effects across organ systems His work has established BPC-157 as one of the most comprehensively studied components in peptide-based regenerative research, though human clinical validation remains completely absent

Exploring NNMT: from metabolic pathways to therapeutic targets