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Although 3MST and R196G produced almost the same levels of Cys-SSH and GSSH, 3MST generated greater amounts of Cys-SSSH, Cys-SSSSH, GSSSH and GSSSSH than R196G (Fig
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However, in another intervention trial with combination therapy (53), the risk of adverse effects was significantly higher in the Se supplementation group, which we speculate may be related to unclear baseline Se levels in the subjects and a narrower safety window during Se treatment
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