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Furthermore, studies investigating the iron dependency of brain CSCs highlight a growing interest in the biological role of ferritin in these cells, especially given its potential involvement in maintaining their stem-like properties and promoting therapeutic resistance

The lineage-defining transcription factors SOX2 and NKX2-1 determine lung cancer cell fate and shape the tumor immune microenvironment

10.1016/j.jare.2025.05.039

(ii) GC1 has a higher Km (~5 mM) for glutamate/H+, similar to the levels measured in intact mitochondria from the liver and kidney, whereas GC2 has a markedly lower Km (~0.26 mM) and shows low expression in many tissues [39]