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Lone MI, He Z, Stoffella PJ, Yang X (2008) Phytoremediation of heavy metal polluted soils and water: progresses and perspectives

8.1.4 Research limitations and considerations While the evidence is compelling, several limitations must be acknowledged, including the reliance on observational studies for human data, potential confounding factors in epidemiological investigations, and the extrapolation challenges from animal models to human populations

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The protective mechanism of methionine is likely due to its conversion to sulfur-containing amino acids, including cysteine, which are depleted by the renal excretion of sulfated acetaminophen metabolites (50)