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Summary of Evidence Quantity of Research Available A total of 211 citations were identified in the literature search

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Weighting by the number of explants and available treatment conditions was applied to reduce the potential risk of disproportionate influence from sparsely represented samples

Epidemiological studies reveal a significantly elevated cardiovascular mortality rate in chronic kidney disease (CKD) patients, with global CKD-related cardiovascular deaths reaching 1.8 million in 2021 (Martin et al., 2024)
