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Nat Rev Mol Cell Biol 19 , 419435 (2018)
The second step takes place in the gut where the metabolized estrogen is packaged up and eliminated via the stool
10.1038/s41401-020-0397-3 123 TangY.YiT.ChenH.ZhaoZ.LiangZ.ChenH
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Both primary (to reduce exposure) and secondary (to alter metabolism and deposition) interventions can use specific biomarkers as endpoints of efficacy
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