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Oxidative stress then accelerates the aggregation of -synuclein which subsequently binds and sequesters available GSH, creating a destructive feedback loop of protein misfolding and antioxidant loss (Leathem et al., 2022)

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The Bcl-2/Bax ratio increased and cleaved caspase-3 levels dropped, indicating reduced apoptosis (Pyo et al., 2007)