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It seems that the benefits of other healthy ingredients found in fish outweigh the effect of higher TMAO, at least when it comes to heart disease prevention

Aging and bone loss Adverse effects of aging are, in part, attributed to decreases in mitochondrial function and increases mitochondrial oxidant production [141]

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In a comprehensive clinical overview, researchers explain that this buffering system prevents the toxic accumulation of unoxidized, short-chain acyl groups within the mitochondria
