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The active region of TB-500 (the LKKTETQ sequence) binds G-actin monomers, preventing their polymerization into filamentous F-actin

This has been supported by the demonstration of a decrease in serum citrulline in these patients [63]

Apr 28th, 2026 How TB-500 Promotes Recovery and Angiogenesis TB-500 is a synthetic fragment of thymosin beta-4 associated with tissue repair and angiogenesis, but human evidence is limited, it is not FDA-approved, and its safety and effectiveness remain uncertain