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For OA, employing local intra-articular administration is expected to significantly reduce systemic exposure and related immune reactions, thus being considered a more realistic clinical translation pathway (Lin et al., 2024
Non-enzymatic, hydroxyl radical-induced oxidation of free fatty acids results in the formation of isoprostanes, which are considered stable markers of oxidative stress
doi: 10.1016/j.biortech.2020.124150
Their antioxidant activity is one of the main processes
