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It has not yet been incorporated into Western clinical guidelines, but in China berberine is sometimes recommended as an adjunct for dyslipidemia or diabetes management, especially when statins or metformin are insufficient or not tolerated

The compound has been studied in rodent models of tendon transection, ligament injury, bone fracture, and muscle crush with findings that have attracted attention from sports medicine researchers, orthopedic scientists, and the broader athletic research applications community

107 Reduction of the association of astrocytic leaflets with synapses is linked to a decreased expression of ezrin (which is responsible for leaflets extension), while deletion of ezrin increased addictive behaviour

PMID 19423374
