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In HNSCC cell lines, foretinib alone strongly inhibited cell growth (cell IC50 0.610.79 M) and exhibited synergistic inhibition of cell proliferation when combined with the EGFR inhibitor erlotinib [117]

Overall, current evidence suggests that cerebellar inflammation shifts microglial metabolism toward glycolysis, with this transition being more pronounced in females than males (Guillot-Sestier et al., 2021)

The principal epigenetic mechanisms observed in human cells encompass DNA methylation, posttranslational modifications of histones, and the involvement of non-coding RNA molecules, including microRNAs and long non-coding RNAs

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